Soluble guanylate cyclase

Curr Opin Struct Biol. 2006 Dec;16(6):736-43. doi: 10.1016/j.sbi.2006.09.006. Epub 2006 Oct 2.

Abstract

Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep mechanism of sGC activation that involves at least two NO-binding sites. The crystal structure of a member of a recently discovered family of prokaryotic sGC homologues has provided important insights into structure-function relationships within the sGC family of proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Activation
  • Guanylate Cyclase / chemistry*
  • Guanylate Cyclase / metabolism*
  • Heme / chemistry
  • In Vitro Techniques
  • Kinetics
  • Ligands
  • Models, Molecular
  • Nitric Oxide / metabolism
  • Prokaryotic Cells
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / metabolism
  • Signal Transduction
  • Solubility

Substances

  • Ligands
  • Recombinant Proteins
  • Nitric Oxide
  • Heme
  • Guanylate Cyclase